For quite a few years now, I have been carrying a 2" Model 15 S&W almost every day. Once in a while, I will carry a 642 or a 37 instead or in addition.
I carry a Sig P-365 (.380). Now that I'm getting old(er), the .380 version is easier to shoot, and I have a Holson "Carry" RDS on it that vastly improves my accuracy. I feel both comfortable and safe carrying it in an (Alabama) pocket holster.